Radiation induces genomic instability and mammary ductal dysplasia in Atm heterozygous mice
نویسندگان
چکیده
منابع مشابه
ATM in prevention of genomic instability
ATM (ataxia-telangiectasia mutated) kinase is a key factor in DNA damage responses, and mutations in ATM cause AT (ataxia-telangi-ectasia), a form of genomic instability syndrome. 1 Various forms of genotoxic agents that generate DsB (double-stranded DNA breaks) activate ATM and induce DNA damage checkpoint pathways involving cell cycle arrest and repair of legions. ATM plays a central role in ...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2001
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1204589