منابع مشابه
Radiation-induced accelerated senescence
Damage to normal tissue is a limiting factor for clinical radiation for cancer eradication. Ionizing radiation can induce a variety of cellular responses, including apoptosis, necrosis, necroptosis, autophagy, and accelerated senescence. The molecular mechanisms of radiationinduced cellular injury depend on a number of factors, including radiation dosage and dose rate, cell type, transformed st...
متن کاملRadiation-induced accelerated senescence: a fate worse than death?
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متن کاملIonizing radiation-induced foci persistence screen to discover enhancers of accelerated senescence
Much like replicative senescence, the irreversible cell-cycle arrest induced by eroded telomeres, accelerated senescence occurs when replicative cells suffer irreparable DNA double-strand breaks (DSBs). Along with apoptosis and necrosis, senescence is a desirable outcome in cancer treatment with ionizing radiation (IR) or chemotherapy. In both normal and cancer cells, DSBs promote the assembly ...
متن کاملRadiation-induced senescence-like terminal growth arrest in thyroid cells.
Premature senescence may play an important role as an acute, drug-, or ionizing radiation (IR)-inducible growth arrest program along with interphase apoptosis and mitotic catastrophe. The aim of the study was to evaluate whether IR can induce senescence-like phenotype (SLP) associated with terminal growth arrest in the thyroid cells, and if so, to evaluate impact of terminal growth arrest assoc...
متن کاملThe importance of senescence in ionizing radiation-induced tumour suppression.
Cellular senescence is a condition of longlasting proliferation arrest, induced in cells in response to various stressors. These stressors include telomere shortening and/or dysfunction, DNA damage, and oncogene signalling. Epithelial and mesenchymal cells and also tumour cells derived from these tissues are more resistant to radiation-induced apoptosis and respond to irradiation mainly by sene...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2014
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.29457