منابع مشابه
Radial Glial Cells Are They Really Glia?
During the development of the cerebral cortex, radial glia serve as a scaffold to support and direct neurons during their migration. This view is now changing in the light of emerging evidence showing that these cells have a much more dynamic and diverse role. A recent series of studies has provided strong support for their role as precursor cells in the ventricular zone that generate cortical ...
متن کاملEarly evolution of radial glial cells in Bilateria
Bilaterians usually possess a central nervous system, composed of neurons and supportive cells called glial cells. Whereas neuronal cells are highly comparable in all these animals, glial cells apparently differ, and in deuterostomes, radial glial cells are found. These particular secretory glial cells may represent the archetype of all (macro) glial cells and have not been reported from protos...
متن کاملEffect of Prenatal Alcohol Exposure on Radial Glial Cells
Prenatal alcohol (ethanol) exposure can have dramatic effects on the development of the central nervous system [5] (CNS), including morphological abnormalities and an overall reduction [6] in white matter [7] of the brain. The impact of ethanol on neural stem cells [8] such as radial glia [9] (RG) has proven to be a significant cause of these defects, interfering with the creation and migration...
متن کاملRNA Transport: From Head to Toe in Radial Glial Cells
Intracellular mRNA localization critically contributes to proper brain development and function. A recent study demonstrates that mRNAs are actively transported in radial glial cells from the soma to the distal basal endfeet, where they are locally translated.
متن کاملCoevolution of radial glial cells and the cerebral cortex
Radial glia cells play fundamental roles in the development of the cerebral cortex, acting both as the primary stem and progenitor cells, as well as the guides for neuronal migration and lamination. These critical functions of radial glia cells in cortical development have been discovered mostly during the last 15 years and, more recently, seminal studies have demonstrated the existence of a re...
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ژورنال
عنوان ژورنال: Neuron
سال: 2005
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2005.04.012