Rac1 Modulates Endothelial Function and Platelet Aggregation in Diabetes Mellitus
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چکیده
منابع مشابه
Platelet Function in Diabetes Mellitus
Diabetes mellitus is associated with accelerated atherosclerosis and increased morbidity and mortality in micro-and macrovascular complications. The metabolic derangements that accompany diabetes can adversely influence platelets and vascular endothelial function, which may contribute to the pathogenesis of diabetic angiopathy. This thesis aimed to examine the effect of acute and postprandial h...
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Patients With Diabetes Mellitus To the Editor: In the recent article by Tsunekawa et al,1 3 days of therapy with the HMG Co-A reductase inhibitor cerivastatin improved flow-mediated vasodilation (FMD) of the brachial artery in a cohort of 27 older patients with diabetes mellitus (mean age 69.3 3.4 years). We found the results of this investigation puzzling for two reasons. First, we were surpri...
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Platelet activation and thrombus formation are under the control of signaling systems that integrate cellular homeostasis with cytoskeletal dynamics. Here, we identify a role for the ribosome protein S6 kinase (S6K1) and its upstream regulator mTOR in the control of platelet activation and aggregate formation under shear flow. Platelet engagement of fibrinogen initiated a signaling cascade that...
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Platelet adhesiveness has been assessed on whole blood from a series of 34 diabetics and 50 control subjects using adenosine diphosphate (A.D.P.) and by adherence to glass microspherules (ballotini). Using both techniques it was possible to demonstrate a significant increase in platelet adhesiveness in the diabetic patients.
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Patients with diabetes mellitus have an increased risk of thrombosis and accelerated atherogenesis. Increased platelet adhesion and aggregation are noted in vitro. This paper reviews known platelet abnormalities found in patients with diabetes mellitus (DM) and examines the pathophysiology associated with these abnormalities. Four general platelet regions or functional units can be involved in ...
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ژورنال
عنوان ژورنال: Journal of the American Heart Association
سال: 2018
ISSN: 2047-9980,2047-9980
DOI: 10.1161/jaha.117.007322