Rabeprazole exhibits antiproliferative effects on human gastric cancer cell lines
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Rabeprazole exhibits antiproliferative effects on human gastric cancer cell lines
Intracellular proton extrusion in gastric cancer cells has been reported to promote cancer cell survival under acidic conditions via hydrogen/potassium adenosine triphosphatase (H+/K+-ATPase). Rabeprazole is a frequently used second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Therefore, we hypothesized that rabeprazole could reduce the viability of...
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ژورنال
عنوان ژورنال: Oncology Letters
سال: 2014
ISSN: 1792-1074,1792-1082
DOI: 10.3892/ol.2014.2354