R-172. Penetrating ability of human spermatozoa with numerical chromosome aberrations

Chromosome aberrations in human spermatozoa treated with Ca2+ ionophore A23187.

Incorporation of A23187 ionophore into the human-hamster fertilization system clearly improves the ability of human spermatozoa to penetrate zona-free hamster oocytes. Thus, an increasing number of laboratories working in human sperm cytogenetics have substituted classical incubation with Biggers-Whitten-Whittingham (BWW) medium plus human serum albumin (HSA) by pretreatment of spermatozoa with...

Radiation- and chemical-induced structural chromosome aberrations in human spermatozoa.

Previous studies on the clastogenic effects of mutagens on human sperm chromosomes were reviewed. A marked increase of structural chromosome aberrations (SCAs) has been reported in the spermatozoa irradiated in vitro with five kinds of ionizing radiation (137Cs gamma-, 60Co gamma-, X-, and 3H beta-rays and 252Cf neutrons). The micronucleus (MN) test with hybrid two-cell embryos generated from h...

Low incidence of chromosome aberrations in spermatozoa of fertile boars.

Chromosomal imbalance in gametes and embryos is one of the factors contributing to early embryonic mortality. Although the rate of chromosomally abnormal sperm cells is low and usually does not exceed 1%, there is no clear indication of fertilizing potential of such gametes. The aim of the experiment was to investigate the type and incidence of numerical chromosomal aberrations in spermatozoa p...

Elimination of chromosome aberrations from human lymphocytes.

Multiple Numerical Chromosome Aberrations in Carcinogenesis: The Kidney Cancer Model

Multiple numerical chromosome aberrations in carcinogenesis: The kidney cancer model Dear Sir, This letter summarizes the talk I gave at the 2nd Conference on Aneuploidy and Cancer: Clinical and Experimental Aspects, in Oakland, California, after the kind invitation of Peter Duesberg from the University of California, Berkeley. The conference addressed the issue of whether aneuploidy or gene mu...