Quorum sensing systems differentially regulate the production of phenazine-1-carboxylic acid in the rhizobacterium Pseudomonas aeruginosa PA1201
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چکیده
منابع مشابه
The phenazine pyocyanin is a terminal signalling factor in the quorum sensing network of Pseudomonas aeruginosa.
Certain members of the fluorescent pseudomonads produce and secrete phenazines. These heterocyclic, redox-active compounds are toxic to competing organisms, and the cause of these antibiotic effects has been the focus of intense research efforts. It is largely unknown, however, how pseudomonads themselves respond to - and survive in the presence of - these compounds. Using Pseudomonas aeruginos...
متن کاملA kinetic model for phenazine-1-carboxylic acid production by pseudomonas sp. M18G
The development of optimal bacterial strains for industrial scale of fermentation would benefit from a quantitative model of rate of gene expression from DNA to RNA, from DNA to protein, and ultimately from DNA to the metabolites. In this study, we developed such a model for phenazine-1-carboxylic acid (PCA) biosynthesis in Pseudomonas sp. strain M18G. The PCA biosynthesis is controlled by anop...
متن کاملQuorum-Sensing Regulator LasR in Pseudomonas aeruginosa
± Current Address: Department of Microbiology, University of Washington School of 21 Medicine, 1959 NE Pacific St., Room K-360, Seattle, WA 98195-7242. 22 23 ね Current address: Department of Molecular, Cellular and Developmental Biology, 24 219 Prospect St., Yale University, New Haven, CT 06471 25 26 * Corresponding author. Mailing address: Department of Molecular, Cellular and 27 Developmental...
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In a process termed quorum sensing, bacteria use diffusible chemical signals to coordinate cell density-dependent gene expression. In the human pathogen Pseudomonas aeruginosa, quorum sensing controls hundreds of genes, many of which encode extracellular virulence factors. Quorum sensing is required for P. aeruginosa virulence in animal models. Curiously, quorum sensing-deficient variants, most...
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Pseudomonas aeruginosa controls several genes in a cell density-dependent manner through a phenomenon termed quorum sensing. The transcriptional activator protein of the las quorum-sensing system is encoded for by the lasR gene, which is at the top of a quorum-sensing hierarchy. The activation of LasR as a transcriptional activator induces the expression of multiple genes that code for factors ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep30352