Quinupristin/Dalfopristin Therapy for Infections Due to Vancomycin-Resistant Enterococcus faecium
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چکیده
منابع مشابه
Linezolid treatment for osteomyelitis due to vancomycin-resistant Enterococcus faecium.
The incidence of nosocomial infections caused by vancomycin-resistant enterococci has risen substantially during the past 15 years. We report the use of linezolid for the successful treatment of hip prosthesis infection associated with osteomyelitis due to vancomycin-resistant Enterococcus faecium.
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An outbreak of infections due to vancomycin-resistant Enterococcusfaecium (VREF) was recently observed in a hospital in Southern California. Several patients developed fatal bacteremia or intraabdominal infection due to VREF. The gastrointestinal tract is the principal site of colonization of VREF, and prior colonization with resistant bacteria often preceded the development of life-threatening...
متن کاملTreatment of vancomycin-resistant Enterococcus faecium infections with quinupristin/dalfopristin.
Clinicians caring for patients with vancomycin-resistant Enterococcus faecium (VREF) infections face severe constraints in the selection of treatment. Quinupristin/dalfopristin (Synercid) is active in vitro against VREF, with a MIC(90) of 1.0 microg/mL. We investigated the clinical efficacy and safety of this agent in a multicenter, prospective, noncomparative, emergency-use study of 396 patien...
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We compared the activities of linezolid (25 mg/kg of body weight, administered intraperitoneally every 8 h) and of vancomycin (25 mg/kg of body weight, administered intraperitoneally every 8 h) in a rat model of vanA vancomycin-resistant Enterococcus faecium experimental endocarditis. Results were expressed as median log(10) CFU per gram of vegetation after 3 days of treatment. The median log(1...
متن کاملHeat tolerance of vancomycin resistant Enterococcus faecium.
The heat tolerance of 27 Enterococcus faecium isolates in water was studied. Stationary phase cultures including vancomycin resistant and sensitive clinical and food isolates were exposed to heat at 60 degrees, 65 degrees, 71 degrees, and 80 degrees C for one, three, 10, and 30 minutes and the log10 reductions in bacterial counts were determined. Exposure at 71 degrees and 80 degrees C resulted...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2000
ISSN: 1058-4838,1537-6591
DOI: 10.1086/313766