Quinone-Enhanced Reduction of Nitric Oxide by Xanthine/Xanthine Oxidase

A Theoretical Study of Nitric Oxide Reduction in Heme-Copper Oxidase and Nitric Oxide Reductase

Single-electron reduction of quinone and nitroaromatic xenobiotics by recombinant rat neuronal nitric oxide synthase.

We examined the kinetics of single-electron reduction of a large number of structurally diverse quinones and nitroaromatic compounds, including a number of antitumour and antiparasitic drugs, and nitroaromatic explosives by recombinant rat neuronal nitric oxide synthase (nNOS, EC 1.14.13.39), aiming to characterize the role of nNOS in the oxidative stress-type cytotoxicity of the above compound...

Enhanced Cell Proliferation Induced by Nitric Oxide

Nitric oxide (NO·) regulates multiple physiological functions including cell proliferation. The regulatory action of NO· on cell proliferation is exerted in a bimodal mode, enhancing and inhibiting the progression of the proliferative process depending on the actual concentration of NO· encountered by the cell. Although not all details are understood, the cytostatic action of NO·, when attained...

Oxygen reduction by nitric-oxide synthases.

Nitric-oxide synthases (NOS, EC 1.14.13.39) are hemeproteins that catalyze oxidation of L-arginine to NOz and L-citrulline. Three main isozymes exist in mammals that are regulated by distinct genes (1–6): a constitutive neuronal NOS (nNOS or NOS I), (7, 8), an endotoxinand cytokine-inducible NOS (iNOS or NOS II) (9, 10), and a constitutive endothelial NOS (eNOS or NOS III) (11). Although NOS ha...

Rapid reduction of nitric oxide by mitochondria, and reversible inhibition of mitochondrial respiration by nitric oxide.

Nitric oxide (NO) inhibited the respiration rate of mitochondria isolated from rat heart at sub-micromolar concentrations of NO. The inhibition was rapidly and completely reversible, indicating that NO does not damage mitochondria. The sensitivity of respiration to NO depended on the oxygen concentration, substrate type and respiratory state of the mitochondria, consistent with NO competing wit...