Quinolactacins A1 and A2, New Acetylcholinesterase Inhibitors from Penicillium citrinum.
نویسندگان
چکیده
منابع مشابه
Quinolactacins A1 and A2, new acetylcholinesterase inhibitors from Penicillium citrinum.
Alzheimer disease is a neurodegenerative disorder that is the most commoncause of dementia amongthe elderly. The neurophathological evidences have demonstrated that cholinergic functions declined in the basal forebrain and cortex in senile dementia of the Alzheimer type1>2). Accordingly, enhancement of cholinergic neurotransmission have been considered as one potential therapeutic approach agai...
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In the course of our previous work we isolated alkaloids such as agroclavine-I and epoxy-agroclavine-I from Penicillium citrinum VKM FW-800 as a microorganism isolated from permafrost1,2). This fungus was shown to coproduce two other alkaloid compounds, which were extractable only under acidic conditions. Positive staining by Dragendorff's reagent but negative Ehrlich reaction suggested the occ...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2001
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.54.831