Quest to find the optimal duration

Statistical Study to Find the Optimal Dose of the First Phase in Leukemia Patients

Abstract. In this paper, a structured framework for determining the optimal dose of the first phase in leukemia patients is presented. And here we describe and discuss the key parameters that are needed to set up and run a CRM trial. These are: number of doses; maximum tolerable dose; Target Toxicity Level Dose-toxicity model; Dose-toxicity skeleton; Sample size and cohort size and Stopping ru...

A quest to find cures for paediatric cancers

Adaptive Techniques to find Optimal Planar Boxes

Given a set P of n planar points, two axes and a realvalued score function f() on subsets of P , the Optimal Planar Box problem consists in finding a box (i.e. an axis-aligned rectangle) H maximizing f(H ∩ P ). We consider the case where f() is monotone decomposable, i.e. there exists a composition function g() monotone in its two arguments such that f(A) = g(f(A1), f(A2)) for every subset A ⊆ ...

Extension of VIKOR Method to Find an Optimal Layout for Fixture's Supporting Points in Order to Reduce Work Piece Deformation

In automotive industry fixtures have a direct effect on product manufacturing quality, productivity and cost, as a result fixtures, particularly welding fixture, play a crucial role in the auto industry. The fixture is a special tool for holding a work piece in proper position during manufacturing operation, so in the phase of the fixture design process positioning pins and surfaces are used to...

An Empirical Quest for Optimal Rule Learning Heuristics An Empirical Quest for Optimal Rule Learning Heuristics

The primary goal of the research reported in this paper is to identify what criteria are responsible for the good performance of a heuristic rule evaluation function in a greedy topdown covering algorithm. We first argue that search heuristics for inductive rule learning algorithms typically trade off consistency and coverage, and we investigate this trade-off by determining optimal parameter s...