Quantitative MR imaging of two-pool magnetization transfer model parameters in myelin mutant shaking pup
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چکیده
منابع مشابه
Quantitative MR imaging of two-pool magnetization transfer model parameters in myelin mutant shaking pup
Magnetization transfer (MT) imaging quantitatively assesses cerebral white matter disease through its sensitivity to macromolecule-bound protons including those associated with myelin proteins and lipid bilayers. However, traditional MT contrast measured by the MT ratio (MTR) lacks pathologic specificity as demyelination, axon loss, inflammation and edema all impact MTR, directly and/or indirec...
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Introduction: Multiple sclerosis (MS) is characterized by lesions in the white matter (WM) of the central nervous system. Magnetic resonance imaging is the most specific and sensitive method for diagnosis of multiple sclerosis. However, the ability of conventional MRI to show histopathologic heterogeneity of MS lesions is insufficient. Quantitative magnetization transfer imaging (qMTI) is a rel...
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Introduction: Quantitative magnetization transfer imaging (QMTI) [1] allows in vivo mapping of the parameters of a two-pool model of MT in tissue [2] by the analysis of off-resonance saturation data, and is useful in the study of human white matter (WM). The two-pool model parameters are the restricted-to-free proton pool size ratio (F), the forward magnetization transfer rate (kf), and the rel...
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Cross relaxation between macromolecular protons and water protons is known to be important in biologic tissue. In magnetic resonance (MR) imaging sequences, selective saturation of the characteristically short T2 macromolecular proton pool can produce contrast called magnetization transfer contrast, based on the cross-relaxation process. Selective saturation can be achieved with continuous wave...
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ژورنال
عنوان ژورنال: NeuroImage
سال: 2012
ISSN: 1053-8119
DOI: 10.1016/j.neuroimage.2012.05.077