Quantification of Chemical Peptide Reactivity for Screening Contact Allergens: A Classification Tree Model Approach
نویسندگان
چکیده
منابع مشابه
Quantification of chemical peptide reactivity for screening contact allergens: a classification tree model approach.
In the interest of reducing animal use, in vitro alternatives for skin sensitization testing are under development. One unifying characteristic of chemical allergens is the requirement that they react with proteins for the effective induction of skin sensitization. The majority of chemical allergens are electrophilic and react with nucleophilic amino acids. To determine whether and to what exte...
متن کاملDevelopment of a peptide reactivity assay for screening contact allergens.
Allergic contact dermatitis resulting from skin sensitization is a common occupational and environmental health problem. In recent years, the local lymph node assay (LLNA) has emerged as a practical option for assessing the skin sensitization potential of chemicals. In addition to accurate identification of skin sensitizers, the LLNA can also provide a reliable measure of relative sensitization...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2007
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfm064