QUALITY CONTROL TESTING OF CONVENTIONAL CLOPIDOGREL BISULFATE TABLETS MARKETED IN IRAQ

Objective: This study was employed to evaluate the quality of marketed oral tablets containing clopidogrel bisulfate. Tablets produced by various companies and commercialized in Iraq market were used study. Methods: Batches bisulfate conventional (containing 75 mg drug) exposed control tests. These tests involved friability, weight variation, hardness, drug content, disintegration time, vitro release study; these conducted depending on USP pharmacopeia. Results: The data indicate that all batches complied with limitations pharmacopeia for variation weight, results hardness 7.2-9.6 Kg/cm2. Friability value (% loss) less than one, which within required limits. time 25 min both artificial gastric fluid (AGF) intestinal (AIF). Drug content observed between 97.1 % 99.8 %, indicating compliance limits (85-115 %). An greater 80 min. Conclusion: All manufactured criteria tablet manufacturing. showed acceptable pharmaceutical properties (effectiveness safety) lie