Quality and Stability Evaluation of Extemporaneously Compounded Losartan Potassium Oral Suspension at the Hospital Pharmacy
نویسندگان
چکیده
Aims: The purpose of this study was to evaluate the quality an extemporaneous formulation losartan potassium oral suspensions from crushed tablets ensure that compounded suspension maintained its attributes during storage period.
 Methodology: Losartan were extemporaneously in same way they are prepared for patients at a hospital pharmacy. kept refrigerator 4°C and evaluated immediately after 9, 18, 28 days. Suspension ease redispersion, color, odor, pH, particle size, zeta potential, viscosity, sedimentation volume all evaluated. In addition, microbiological stability, drug content, dissolution assessed.
 Results: During period, retained color pH profile remained consistent. Moreover, easily resuspended homogeneous liquid with gentle shaking, no caking detected. Furthermore, results test revealed microbial growth. content uniformity met pharmacopeial requirements. findings compounding procedure reliable capable producing 2.5 mg/mL using commercially available Ora-Blend as suspending vehicle. days (4°C), had acceptable features.
 Conclusion: Extemporaneously allows physicians prescribe variable dose adjusts each patient’s needs, providing treatment when dosage form is unavailable.
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ژورنال
عنوان ژورنال: Journal of pharmaceutical research international
سال: 2023
ISSN: ['2456-9119']
DOI: https://doi.org/10.9734/jpri/2023/v35i147371