Qualitative and quantitative changes in skeletal muscle from heart failure patients
نویسندگان
چکیده
منابع مشابه
Muscle wasting in icu trauma patients: quantitative and qualitative changes
Methods Fifteen ICU patients were studied on day 1 and on day 20 after trauma and compared with 15 anorexic patients with severe malnutrition (BMI < 17) volunteering to participate to the study. Muscle mass was evaluated by ultrasound scan, a recently validated method with several advantages: it is accurate, non-invasive, inexpensive, easily repeatable, easy to perform at bedside and apt to det...
متن کاملSkeletal muscle changes in patients with chronic heart failure before and after treatment with enalapril.
To evaluate if enalapril treatment can influence skeletal muscle metabolism and histology we investigated 26 patients with congestive heart failure and 20 normal subjects. The patients were treated with enalapril for 3 months in addition to diuretics and digitalis. Biopsies from the lateral vastus muscle were taken before and after treatment. Citrate synthetase, 3-hydroxyacyl-CoA dehydrogenase ...
متن کاملApoptosis in the skeletal muscle of patients with heart failure: investigation of clinical and biochemical changes.
OBJECTIVE To investigate the contribution of apoptosis in the development of the skeletal myopathy in chronic heart failure. DESIGN The electrophoretic pattern of myosin heavy chains (MHC), fibre cross sectional area, number of in situ nick end labelling (TUNEL) positive apoptotic myocyte nuclei, and the tissue levels of caspase-3, Bcl-2, and ubiquitin were determined in biopsies taken from t...
متن کاملContribution of intrinsic skeletal muscle changes to 31P NMR skeletal muscle metabolic abnormalities in patients with chronic heart failure.
Patients with heart failure frequently exhibit abnormal skeletal muscle metabolic responses to exercise, as assessed with 31P NMR. To investigate whether these metabolic abnormalities are due to intrinsic skeletal muscle changes, we performed gastrocnemius muscle biopsies on 22 patients with heart failure (peak VO2, 15.4 +/- 4.7 ml/kg/min; ejection fraction, 20 +/- 7%) and on eight normal subje...
متن کاملSkeletal muscle reflex in heart failure patients: role of hydrogen.
BACKGROUND An important role of the increased stimulation of skeletal muscle ergoreceptors (intramuscular afferents sensitive to products of muscle work) in the genesis of symptoms of exertion intolerance in chronic heart failure (CHF) has been proposed. With the use of selective infusions and dietary manipulation methods, we sought to identify the role of H+, K+, lactate, and peripheral hemody...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.954.2