QTc interval prolongation, COVID-19 and chloroquine
نویسندگان
چکیده
منابع مشابه
Ketamine-induced QTc interval prolongation
Sir, Ketamine is a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor. It is widely used as a dissociative anesthetic and is also used as an adjunct in pain management, particularly in opioid-tolerant patients. It blocks calcium channels and depresses sodium channel function as well as having anticholinergic effects. It inhibits the re-uptake of the catecholamines and may hav...
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PURPOSE Although the ABCB1 (P-glycoprotein) drug transporter is a constituent of several blood-tissue barriers (i.e., blood-brain and blood-nerve), its participation in a putative blood-heart barrier has been poorly explored. ABCB1 could decrease the intracardiac concentrations of drugs that cause QT prolongation and cardiotoxicity. EXPERIMENTAL DESIGN ABCB1-related romidepsin transport kinet...
متن کاملProlongation of the QTc interval in patients with cirrhosis
and in many congenital and acquired conditions as cardiac disease, electrolyte abnormalities, and many commonly used drugs. Additionally, acquired prolongation of QT interval has been documented in alcoholic liver disease, cirrhosis and liver failure. Liver transplantation in the latter group has been shown to reverse this anomaly. The QT prolongation was found to be independent of the etiology...
متن کاملFactors influencing QTc interval prolongation during kidney transplantation.
BACKGROUND During renal transplantation, factors causing disturbances of the repolarization process, defined by the QT interval, may lead to ventricular arrhythmias. The aim of this study was to determine a relationship between QT interval prolongation and metabolic homoeostasis, and durations of cold ischemia time (CIT) and warm ischemia time (WIT) during renal transplantation. MATERIAL/METH...
متن کاملProphylactic Effect of Chloroquine and Hydroxy chloroquine in COVID-19 Treatment
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute respiratory disease, named ‘coronavirus disease 2019’ (COVID-19), which threatens human health and public safety.Hydroxychloroquine (HCQ) is an anti-malaria drug; its antiviral properties are controversial,and some in vitr...
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ژورنال
عنوان ژورنال: Netherlands Heart Journal
سال: 2020
ISSN: 1568-5888,1876-6250
DOI: 10.1007/s12471-020-01506-x