QT interval prolongation associated with sibutramine treatment
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Severe QT interval prolongation associated with moxifloxacin: a case report
INTRODUCTION The QT interval prolongation is an adverse effect associated with moxifloxacin. This adverse effect can lead to potentially life-threatening arrhythmias such as Torsades de pointes. We describe a case of severe QT interval prolongation associated with moxifloxacin which may cause the development of Torsades de pointes. There have been no reported case of severe corrected QT interva...
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Until recently, cardiac toxicity manifesting in the form of arrhythmias related to QT interval prolongation was uncommonly appreciated within the antimicrobial class of drugs, but it was well described among antiarrhythmic agents. Antimicrobials that are associated with QT prolongation include the macrolides/ketolides, certain fluoroquinolones and antimalarials, pentamidine, and the azole antif...
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N Engl J Med 2004;350:1013-22. Copyright © 2004 Massachusetts Medical Society. n the past decade, the single most common cause of the withdrawal or restriction of the use of drugs that have already been marketed has been the prolongation of the QT interval associated with polymorphic ventricular tachycardia, or torsade de pointes (Fig. 1), which can be fatal. 1 Nine structurally unrelated drugs...
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In hypertensive patients single doses of ketanserin 40 mg prolonged the corrected QT interval (QTc) for at least 8 hours, with a maximal increase of 35 ms (P less than 0.001, n = 6) after 2 hours. During chronic dosing (20 and 40 mg b.d.) the QTc was further prolonged, by 46 and 45 ms respectively. QTc prolongation after treatment with a mean dose of 73 mg/day for 7 weeks (n = 26) was significa...
متن کاملDrug-induced prolongation of the QT interval.
N Engl J Med 2004;350:1013-22. Copyright © 2004 Massachusetts Medical Society. n the past decade, the single most common cause of the withdrawal or restriction of the use of drugs that have already been marketed has been the prolongation of the QT interval associated with polymorphic ventricular tachycardia, or torsade de pointes (Fig. 1), which can be fatal. 1 Nine structurally unrelated drugs...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2006
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.2006.02574.x