QSTR study of four synthesized nitrobenzene derivatives

In - vitro antioxidant and antibacterial activities of the four synthesized indole derivatives

The indole nucleus seems to be a promising basis for design and synthesis of new derivatives able to protect oxidative stress in a variety of acute and chronic pathologies. The paper presents an overview of indole derived compounds in which inhibitory action has been demonstrated against potent microbes and also tested for antioxidant activity. Cellular damage caused by reactive oxygen species ...

Computational Study of Quinolone Derivatives to Improve their Therapeutic Index as Anti-malaria Agents: QSAR and QSTR

Malaria is a parasitic disease with limited chemotherapy options. Chemotherapy options are limited; moreover, drug resistant frequently occurs. The speed of drug development should be faster to overcome the emerging drug resistance. In the current study, a series of quinolone derivatives were subjected to quantitative structure activity relationship to identify the ideal physicochemical charact...

Application of topological and physicochemical descriptors: QSTR analysis of the toxicity of benzene derivatives

Computational Study of Quinolone Derivatives to Improve their Therapeutic Index as Anti-malaria Agents: QSAR and QSTR

Malaria is a parasitic disease with limited chemotherapy options. Chemotherapy options are limited; moreover, drug resistant frequently occurs. The speed of drug development should be faster to overcome the emerging drug resistance. In the current study, a series of quinolone derivatives were subjected to quantitative structure activity relationship to identify the ideal physicochemical charact...

Computational Study of Quinolone Derivatives to Improve their Therapeutic Index as Anti-malaria Agents: QSAR and QSTR

Malaria is a parasitic disease caused by five different species of Plasmodium. More than 40% of the world's population is at risk and malaria annual incidence is estimated to be more than two hundred million, malaria is one of the most important public health problems especially in children of the poorest parts of the world, annual mortality is about 1 million. The epidemiological status of the...