Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury
نویسندگان
چکیده
منابع مشابه
Pyruvate Dehydrogenase Kinase 4
OBJECTIVE Pyruvate dehydrogenase complex (PDC) serves as the metabolic switch between glucose and fatty acid utilization. PDC activity is inhibited by PDC kinase (PDK). PDC shares the same substrate, i.e., pyruvate, as glyceroneogenesis, a pathway controlling fatty acid release from white adipose tissue (WAT). Thiazolidinediones activate glyceroneogenesis. We studied the regulation by rosiglita...
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Hyperhomocysteinemia (HHcy) has been linked to several clinical manifestations including chronic kidney disease. However, it is not known whether HHcy has a role in the development of acute kidney injury (AKI). In the present study, we reported that HHcy mice developed more severe renal injury after cisplatin injection and ischemia-reperfusion injury shown as more severe renal tubular damage an...
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Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors. A known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates dose reduction or withdrawal. Recurrent episode...
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The pathogenesis of cisplatin-induced acute kidney injury (AKI) is characterized by tubular cell apoptosis and inflammation. However, the molecular mechanisms are not fully understood. We found that CXCL16 was induced in renal tubular epithelial cells in response to cisplatin-induced AKI. Therefore, we investigated whether CXCL16 played a role in cisplatin-induced tubular cell apoptosis and inf...
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Background and objectives: Cisplatin (CP), as an anticancer drug, causes nephrotoxicity. Zataria multiflora Boiss. (ZM), a plant which has been used as a herbal medicine for a variety of ailments. Our study aimed to examine the effects of ZM on cisplatin induced nephrotoxicity. Methods: Thirty-two male mice were randomly divided into four groups. The co...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2017
ISSN: 0085-2538
DOI: 10.1016/j.kint.2016.10.011