Pyrroloquinoline Quinone (PQQ) Prevents Cognitive Deficit Caused by Oxidative Stress in Rats
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Pyrroloquinoline Quinone (PQQ) Prevents Cognitive Deficit Caused by Oxidative Stress in Rats
The effects of pyrroloquinoline quinone (PQQ) and coenzyme Q(10) (Co Q(10)), either alone or together, on the learning ability and memory function of rats were investigated. Rats fed a PQQ-supplemented diet showed better learning ability than rats fed a CoQ(10)-supplemented diet at the early stage of the Morris water maze test. The combination of both compounds resulted in no significant improv...
متن کاملThe pyrroloquinoline quinone (PQQ)-containing quinoprotein dehydrogenases.
L. (1995) Biochemistry 34, 11080-1 1089 10 Friden, H. and Hederstedt, L. (1990) Mol. Microbiol. 4, 1045-1056 1 1 Nakamura, K., Yamaki, M., Sarada, M., Nakayama, S., Vibat, C. R. T., Gennis, R. B., Nakayashiki, T., Inokuchi, H., Kojima, S. and Kita, K. (1996) J. Biol. Chem. 271, 521-527 12 Hagerhall, C. and Hederstedt, L. (1996) FEBS Lett. 389, 25-31 13 Pennoyer, J. D., Ohnishi, T. and Trumpower...
متن کاملRegulation of oxidative stress and lipid peroxidation in PTU induced mice, treated with Pyrroloquinoline quinone (PQQ)
Hitherto unknown effects of Pyrroloquinoline quinone (PQQ) in 6-n-propyl-2-thiouracil (PTU)induced oxidative stress and lipid peroxidation were investigated in adult mice. Animals received either PTU (0.05% in drinking water) alone for 5 weeks or PTU + three different concentrations of PQQ, after which alterations in tissue lipid peroxidation (LPO) and in enzymatic activities of superoxide dism...
متن کاملA subchronic oral toxicity study on pyrroloquinoline quinone (PQQ) disodium salt in rats.
A subchronic oral toxicity study on pyrroloquinoline quinone (PQQ) disodium salt was performed in rats. Sprague-Dawley rats were randomly divided into four groups (10 rats/sex/group) and administered with PQQ disodium salt at doses of 0 (control), 100, 200 and 400 mg/kg bw/day by gavage for 13 weeks. Daily clinical observations and weekly measurement of body weights and food consumption were co...
متن کاملNephrotoxicity of pyrroloquinoline quinone in rats.
When pyrroloquinoline quinone (PQQ) was intraperitoneally injected into rats daily for 4 days at a dose of 11.5 mg/kg body weight/injection, functional and morphologic changes of the kidneys were clearly observed. The most prominent finding was necrotic and degenerative changes of the proximal tubular epithelium as well as hematuria and an elevation of serum creatinine concentration.
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ژورنال
عنوان ژورنال: Journal of Clinical Biochemistry and Nutrition
سال: 2008
ISSN: 1880-5086,0912-0009
DOI: 10.3164/jcbn.2008005