Pyrroloquinoline quinone as cofactor in galactose oxidase (EC 1.1.3.9)
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منابع مشابه
Pyrroloquinoline Quinone as Cofactor in Galactose Oxidase
Galactose oxidase from Dactylium dendroides was shown to contain one molecule of covalently bound pyrroloquinoline quinone (PQQ)/enzyme molecule. From the spectroscopic characteristics reported for the enzyme forms, a mechanistic role for PQQ could be deduced. In analogy with other quinoproteins, the initial formation of a PQQ-substrate adduct is proposed. Following internal hydrogen transfer, ...
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Diamine oxidase was prepared from pea (Pisum sativum) seedlings by a new purification procedure involving two h.p.l.c. steps. We studied the optical and electrochemical properties of the homogeneous enzyme and also analysed the hydrolysed protein by several methods. The data presented here suggest that the carbonyl cofactor of diamine oxidase is firmly bound pyrroloquinoline quinone.
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This paper highlights some features, which describe the characterization and physiological importance of Pyrroloquinoline quinone (PQQ), discovered more than forty years ago. Mechanism of biosynthetic pathway of PQQ is described based on sequence analysis and homology models. But still now all activities of PQQ are not discovered. PQQ is not only a bacterial redox cofactor in alcohol oxidation ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1989
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)83110-6