Pyrophosphate Activation in Hypoxanthine−Guanine Phosphoribosyltransferase with Transition State Analogue
نویسندگان
چکیده
منابع مشابه
Enzymatic transition state theory and transition state analogue design.
The incredible catalytic rate enhancements caused by enzymes led Linus Pauling (1) to suggest that enzymes bind tightly to substrates distorted toward the transition state, thereby concentrating them and enforcing catalysis. Wolfenden (2) explained that chemically stable analogues that resemble the transition state would be expected to bind more tightly than substrate by factors resembling the ...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2010
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi100012u