منابع مشابه
Polyamides for Nuclecacid Delivery
(54) POLYAMIDES FOR NUCLEICACID CI2N IS/II (2006.01) DELIVERY A 6LX 3L/705 (2006.01) C7H 2L/04 (2006.01) (76) Inventor: Theresa M. Reineke, Blacksburg, C08G 69/48 (2006.01) VA (US) C08G 63/9. (2006.01) C7H 2L/02 (2006.01) Correspondence Address: A63L/7II (2006.01) DINSMORE & SHOHL, LLP CI2N IS/00 (2006.01) 1900 CHEMED CENTER, 255 EAST FIFTH A63L/7088 (2006.01) STREET CINCINNATI, OH 45202 (US) (...
متن کاملPhotodeprotectable N-Alkoxybenzyl Aromatic Polyamides
N-alkoxybenzyl aromatic polyamides were synthesized by polycondensation of N-alkoxybenzyl aromatic diamine with equimolar dicarboxylic acid chloride in the presence of 2.2 equiv. of pyridine at room temperature for 2 days. The obtained polyamides were mainly cyclic polymers, as determined by means of matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry, and s...
متن کاملSolution-phase synthesis of pyrrole-imidazole polyamides.
Pyrrole-imidazole polyamides are DNA-binding molecules that are programmable for a large repertoire of DNA sequences. Typical syntheses of this class of heterocyclic oligomers rely on solid-phase methods. Solid-phase methodologies offer rapid assembly on a micromole scale sufficient for biophysical characterizations and cell culture studies. In order to produce gram-scale quantities necessary f...
متن کاملMicrowave Assisted Synthesis of Py-Im Polyamides
Microwave synthesis was utilized to rapidly build Py-Im polyamides in high yields and purity using Boc-protection chemistry on Kaiser oxime resin. A representative polyamide targeting the 5'-WGWWCW-3' (W = A or T) subset of the consensus Androgen and Glucocorticoid Response Elements was synthesized in 56% yield after 20 linear steps and HPLC purification. It was confirmed by Mosher amide deriva...
متن کاملDevelopment of Pyrrole-Imidazole (PI) Polyamides as
Disclosed is an inhibitor of the expression of CTGF gene, which comprises a pyrrole-imidazole polyamide. The pyrrole-imidazole polyamide has an N-methylpyrrole unit (hereinafter, referred to as “Py”), an N-methylimidazole unit (hereinafter, referred to as “Im”) and a ϝ-aminobutanoic acid unit. In the pyrrole-imidazole polyamide, the region of the ϝ-aminobutanoic acid unit is folded to form an U...
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ژورنال
عنوان ژورنال: Journal of Research of the National Bureau of Standards
سال: 1958
ISSN: 0091-0635
DOI: 10.6028/jres.060.005