Pyrogallol-Based Molecules as Potent Inhibitors of the Antiapoptotic Bcl-2 Proteins
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چکیده
منابع مشابه
Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins.
Guided by a combination of nuclear magnetic resonance binding assays and computational docking studies, we synthesized a library of 5,5' substituted Apogossypol derivatives as potent Bcl-XL antagonists. Each compound was subsequently tested for its ability to inhibit Bcl-XL in an in vitro fluorescence polarization competition assay and exert single-agent proapoptotic activity in human cancer ce...
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ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 2007
ISSN: 0022-2623,1520-4804
DOI: 10.1021/jm061400l