منابع مشابه
Agranulocytosis during malaria prophylaxis with Maloprim (pyrimethamine and dapsone).
A case of agranulocytosis during malaria prophylaxis with Maloprim (pyrimethamine and dapsone) is described. At the recommended dose of one tablet weekly this is apparently a rare occurrence but highlights one of the hazards in a changing climate of malarial prophylaxis in which the use of Maloprim is increasing.
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The spread of high-level pyrimethamine resistance in Africa threatens to curtail the therapeutic lifetime of antifolate antimalarials. We studied the possible evolutionary pathways in the evolution of pyrimethamine resistance using an approach in which all possible mutational intermediates were created by site-directed mutagenesis and assayed for their level of drug resistance. The coding seque...
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ژورنال
عنوان ژورنال: BMJ
سال: 1955
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.4907.207