Pyridoxal Phosphate vs Pyridoxine for Intractable Seizures
نویسندگان
چکیده
منابع مشابه
Pyridoxal phosphate is better than pyridoxine for controlling idiopathic intractable epilepsy.
AIM To study the difference between pyridoxine (PN) and its active form, pyridoxal phosphate, (PLP) in control of idiopathic intractable epilepsy in children. METHODS Among 574 children with active epilepsy, 94 (aged 8 months to 15 years) were diagnosed with idiopathic intractable epilepsy for more than six months. All received intravenous PLP 10 mg/kg, then 10 mg/kg/day in four divided doses...
متن کاملHIGH-DOSE ORAL PYRIDOXINE FOR TREATMENT OF PEDIATRIC RECURRENT INTRACTABLE SEIZURES
Intractable epilepsy is a common clinical problem in pediatrics and approximately 13% of children with epilepsy experience intractable seizures. To determine the efficacy of pyridoxine in treating seizures, 30 infants and children with recurrent seizures were enrolled in the present study. All of them were treated with high-dose oral pyridoxine (40 mg/kg/day), as an adjunct to antiepileptic...
متن کاملhigh-dose oral pyridoxine for treatment of pediatric recurrent intractable seizures
intractable epilepsy is a common clinical problem in pediatrics and approximately 13% of children with epilepsy experience intractable seizures. to determine the efficacy of pyridoxine in treating seizures, 30 infants and children with recurrent seizures were enrolled in the present study. all of them were treated with high-dose oral pyridoxine (40 mg/kg/day), as an adjunct to antiepileptic dru...
متن کاملThe Conversion of Pyridoxine Phosphate into Pyridoxal Phosphate in Escherichia Coli.
1. Evidence is presented for the presence of pyridoxine phosphate oxidase in aqueous extracts of Escherichia coli. Some comparison is made with pyridoxamine phosphate oxidase. 2. Isoniazid and iproniazid were found to combine with pyridoxal phosphate, but isoniazid did not combine with either pyridoxamine phosphate or pyridoxine phosphate. Both oxidase activities were somewhat inhibited by benz...
متن کاملInactive mutants of human pyridoxine 5′‐phosphate oxidase: a possible role for a noncatalytic pyridoxal 5′‐phosphate tight binding site
Pyridoxal 5'-phosphate (PLP) is a cofactor for many vitamin B6-requiring enzymes that are important for the synthesis of neurotransmitters. Pyridoxine 5'-phosphate oxidase (PNPO) is one of two enzymes that produce PLP. Some 16 known mutations in human PNPO (hPNPO), including R95C and R229W, lead to deficiency of PLP in the cell and have been shown to cause neonatal epileptic encephalopathy (NEE...
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ژورنال
عنوان ژورنال: Pediatric Neurology Briefs
سال: 2005
ISSN: 2166-6482,1043-3155
DOI: 10.15844/pedneurbriefs-19-5-11