Pyrazinoic acid-Poly(malic acid) biodegradable nanoconjugate for efficient intracellular delivery

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Microbial synthesized biodegradable PHBHHxPEG hybrid copolymer as an efficient intracellular delivery nanocarrier for kinase inhibitor

BACKGROUND Protein Kinases are key regulators of cell function and play essential roles in the occurrence and development of many human diseases. Many kinase inhibitors have been used for molecular targeted treatment of those diseases such as cancer and inflammation. However, those highly hydrophobic kinase inhibitors shared the common features of poor bioavailability and limited in vivo half-l...

متن کامل

Phospho sulfonic acid: an efficient solid acid catalyst for the facile preparation of 1,4-dihydropyridines

A simple and mild one-pot three-component reaction for the preparation 1,4-dihydropyridines has been developed from various aldehyde substrates, 1,3-dicarbonyl compounds (dimedone) and ammonium acetate (Hantzsch method) in the presence of a catalytic amount of phospho sulfonic acid (PSA) as an efficient and heterogeneous solid acid in EtOH at room temperature. Preparation of PSA is straightforw...

متن کامل

Cellular Delivery of Doxorubicin via pH-Controlled Hydrazone Linkage Using Multifunctional Nano Vehicle Based on Poly(β-L-Malic Acid)

Doxorubicin (DOX) is currently used in cancer chemotherapy to treat many tumors and shows improved delivery, reduced toxicity and higher treatment efficacy when being part of nanoscale delivery systems. However, a major drawback remains its toxicity to healthy tissue and the development of multi-drug resistance during prolonged treatment. This is why in our work we aimed to improve DOX delivery...

متن کامل

Phospho sulfonic acid: an efficient solid acid catalyst for the facile preparation of 1,4-dihydropyridines

A simple and mild one-pot three-component reaction for the preparation 1,4-dihydropyridines has been developed from various aldehyde substrates, 1,3-dicarbonyl compounds (dimedone) and ammonium acetate (Hantzsch method) in the presence of a catalytic amount of phospho sulfonic acid (PSA) as an efficient and heterogeneous solid acid in EtOH at room temperature. Preparation of PSA is straightforw...

متن کامل

Magnetic ZnFe2O4@polyhydroxybenzoic acid nanostructure for efficient B.subtilis capturing

Objective(s): This work focuses on preparing an efficient bacterial capture system based on the magnetic polyphenolic nanostructure. For a reason, a one-step hydrothermally route was employed to prepare ZnFe2O4@hydroxybenzoic acid - resorcinol nanohybrid. Methods: The nanostructure was characterized by X–ray diffraction (XRD), field ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Precision Nanomedicine

سال: 2019

ISSN: 2639-9431

DOI: 10.33218/prnano2(3).190523.1