PW01-040 – Definition of polymorphism C3435T MDR1 gene in JIA
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چکیده
منابع مشابه
PW01-040 – Definition of polymorphism C3435T MDR1 gene in JIA
Introduction Juvenile idiopathic arthritis (JIA) is one of the most common rheumatic disease in children. Brug of choice is methotrexate (MTX) cytostatic drug from the group of antimetabolites, folic acid antagonists. According to various authors, about 70% of patients receiving therapy with MTX are in remission for the disease. In 1988, MTX was approved FDA (Food and Drug Administration, USA) ...
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INTRODUCTION Considering the high prevalence of liver tumors and the impact on patient survival, a greater understanding of the biological behavior of those tumors if of great importance. The multidrug resistance gene (MDR1) may present as single nucleotide polymorphism (SNP) which can affect the expression and activity of P-glycoprotein (Pgp), and high expression of Pgp has been associated wit...
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BACKGROUND The multidrug resistance gene 1(MDR1) C3435T polymorphism has been reported to be associated with colorectal cancer (CRC) risk in Asians, however the results were inconsistent. Thus, we performed a meta-analysis to generate large-scale evidence on the association between C3435T polymorphism and CRC risk in Asian populations. METHODS The PubMed, Web of Science, Embase, CNKI, and Chi...
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Background Due to the high prevalence of co-infection by hepatitis C virus (HCV) and human immunodeficiency virus (HIV) and the severity of these infections, the understanding of the biological mechanisms involved in these processes, including viral behavior and host genetic profile, is of great importance for patient treatment and for public health policies.Some single nucleotide polymorphisms...
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Adenosine triphosphate-binding cassette B1 (MDR1multiple drug resistance gene1), a drug transporter gene encodes a transmembrane glycoprotein (P-gp), which functions as an efflux pump for various structurally unrelated anticancer agents and toxins. Our main objective is to study MDR1 gene polymorphism at C3435T in chronic myeloid leukemia (CML) to understand its association with development and...
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ژورنال
عنوان ژورنال: Pediatric Rheumatology
سال: 2013
ISSN: 1546-0096
DOI: 10.1186/1546-0096-11-s1-a93