PV-0049: Recurrent skull base and extra-cranial chordoma following proton therapy: clinical outcomes

Feasibility of proton beam therapy for chordoma and chondrosarcoma of the skull base.

We explored the general feasibility of proton beam therapy for chordoma and chondrosarcoma of the skull base. Clinical records and treatment-planning data of patients with the pathological diagnosis of chordoma or chondrosarcoma were examined. Proton beam therapy was administered for gross tumor mass as well as microscopic residual disease after surgery. The prescribed dose was determined to ma...

Analysis of Clinical Features and Outcomes of Skull Base Chordoma in Different Age-Groups.

OBJECTIVE The objective of the current study was to compare the clinical features and outcomes between younger and older patients with skull base chordoma (SBC). METHODS In this retrospective study, patients with SBC who underwent surgical treatment between February 2005 and December 2014 were included. Clinical features were recorded, including the signal intensity ratio of tumor to brain st...

MRI characterization of skull base chordoma and chondrosarcoma in a patient collective referred for proton radiation therapy

Outcomes and Quality of Life Following Skull Base Surgery

Treatment goals following skull base surgery have shifted over the last decade to improving functional outcomes and quality of life. Given the intimacy of skull base tumors to vital structures, the potential for morbidity, functional impairments, and a decline in quality of life after surgery is possible. The endoscopic endonasal approach may have potential functional outcome and quality of lif...

Genomic and transcriptomic characterization of skull base chordoma

Skull base chordoma is a primary rare malignant bone-origin tumor showing relatively slow growth pattern and locally destructive lesions, which can only be characterized by histologic components. There is no available prognostic or therapeutic biomarker to predict clinical outcome or treatment response and the molecular mechanisms underlying chordoma development still remain unexplored. Therefo...