منابع مشابه
Putting the Squeeze on Test Sequences
Dynamic test sequence compaction is an effective means of reducing test application time and often results in higher fault coverages and reduced test generation time as well. A new algorithm for dynamic test sequence compaction is presented that uses genetic techniques to evolve test sequences. Test sequences provided by a test generator and previously evolved sequences already included in the ...
متن کاملPutting the Squeeze on Airway Epithelia.
Asthma is characterized by chronic inflammation, airway hyperresponsiveness, and progressive airway remodeling. The airway epithelium is known to play a critical role in the initiation and perpetuation of these processes. Here, we review how excessive epithelial stress generated by bronchoconstriction is sufficient to induce airway remodeling, even in the absence of inflammatory cells.
متن کاملDevelopmental Patterning: Putting the Squeeze on Mis-specified Cells
Widely implicated in human disease, abnormal cellular cysts reflect dramatic defects in the maintenance of epithelial integrity. A new study reports that epithelial cysts may arise as a surprisingly general consequence of clonal defects in the specification of cell identity.
متن کاملMechanotransduction: Feeling the Squeeze in the C. elegans Reproductive System
A new study reports that the RhoGAP SPV-1 senses membrane curvature and cell stretch in the Caenorhabditis elegans spermatheca. Without SPV-1, the cells of the spermatheca are hypercontractile, leading to deformation and rapid ejection of the fertilized eggs. The spermatheca may provide a paradigm for understanding how cells detect mechanical stimuli in vivo.
متن کاملCellular mechanotransduction: putting all the pieces together again.
Analysis of cellular mechanotransduction, the mechanism by which cells convert mechanical signals into biochemical responses, has focused on identification of critical mechanosensitive molecules and cellular components. Stretch-activated ion channels, caveolae, integrins, cadherins, growth factor receptors, myosin motors, cytoskeletal filaments, nuclei, extracellular matrix, and numerous other ...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2004
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2004.05.013