Putting the pacemaker channel through its paces to build a better biological pacemaker
نویسندگان
چکیده
منابع مشابه
Pacemaker Twiddler's Syndrome
A 76-yr-old man with unipolar ventricular pacemaker, previously implanted in the right ventricular apex, presented with syncopal attack and twitching of the right pectoralis muscle. He finally was diagnosed as having Twiddler's syndrome. The patient had a pulse rate of 36/min and cannon waves in the neck veins. Chest radiography showed a dislodged pacing lead completely wrapped around the pulse...
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A cardiac biological pacemaker (BP) has been created by suppression of the inward rectifier K(+) current (I(K1)) or overexpression of the hyperpolarization-activated current (I(h)). We theoretically investigated the effects of incorporating I(h), T-type Ca(2+) current (I(Ca,T)), sustained inward current (I(st)), and/or low-voltage-activated L-type Ca(2+) channel current (I(Ca,LD)) on 1) creatio...
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BACKGROUND One key element of natural pacemakers is the pacemaker current encoded by the hyperpolarization-activated nucleotide-gated channel (HCN) gene family. Although HCN gene transfer has been used to engineer biological pacemakers, this strategy may be confounded by unpredictable consequences of heteromultimerization with endogenous HCN family members and limited flexibility with regard to...
متن کاملPacemaker dependency after pacemaker implantation.
BACKGROUND Pacemaker dependency (PD) can be defined as the risk of serious injury or death from sudden pacemaker failure, an event more dangerous than progressive rate decrease. The aim of this study was to evaluate the incidence of PD during long-term follow-up after pacing system implantation. METHODS AND RESULTS The study included 3638 patients (mean age 65.3 +/- 10.2 years). Indications f...
متن کاملPacemaker lead-straight through the heart.
1 of 2 DESCRIPTION A 45-year-old female patient, was admitted with recurrent syncope of 1 month duration. An emergency temporary transvenous right ventricular pacing electrode was placed for complete heart block. The patient developed chest pain and giddiness the following day and electrocardiogram revealed failure to capture and undersensing, with right bundle branch block morphology ( fi gure...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2009
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2009.170720