Putrescine-stimulated Intracellular Ca2+Release for Invasiveness of Rat Ascites Hepatoma Cells
نویسندگان
چکیده
منابع مشابه
Putrescine-dependent invasive capacity of rat ascites hepatoma cells.
The effects of inhibitors of polyamine synthesis on the invasive capacity of rat ascites hepatoma (LC-AH) cells were examined by in vitro assay of penetration of the LC-AH cells through a monolayer of calf pulmonary arterial endothelial (CPAE) cells. Pretreatment of LC-AH cells with alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, before seeding them onto a CPAE ce...
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protein tyrosine phosphatases (ptpases) regulate tyrosine phosphorylation of target proteins involved in several aspects of cellular functions. enzyme activities of the ptpases in cytosolic and particulate fractions of rat ascites hepatoma cell lines were determined and compared with those of normal rat liver. our present data revealed that although there was no neoplatic-specific alteration of...
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Transplabtable Zajdela rat ascites hepatoma cells, previously considered "nonproducers," synthesize detectable amounts of intracellular alpha-fetoprotein (AFP) and fibrinogen, but fail to secret or release these serum proteins. Evidence for defective secretory mechanisms for serum proteins in these hepatoma cells (a) explains the failure to detect AFP in either the serum or ascitic fluid of rat...
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The motility of tumor cells and the liberation of a spreading factor, such as hyaluronidase, have hitherto been regarded as responsible for the in vasive growth of malignant tumors. However, since hyaluronidase does not exist in some kinds of malignant tumors (1, 12), it must be regarded as a nonessential factor in invasiveness (6, 7). Re cently, Cliffton and Grossi (2) reported fibrinolytic ac...
متن کاملMacrophage potentiation of invasive capacity of rat ascites hepatoma cells.
In vitro and in vivo invasive capacities of rat ascites hepatoma cells (AH 130) that had been cultured on the feeder layers of rat macrophages were examined. The in vitro invasive capacity of the tumor cells was measured by their ability to form tumor cell colonies underneath cultured mesothelial cell monolayers; in vivo invasive capacity was examined by the implantation of the tumor cells into...
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ژورنال
عنوان ژورنال: Japanese Journal of Cancer Research
سال: 1998
ISSN: 0910-5050
DOI: 10.1111/j.1349-7006.1998.tb00481.x