Purines. LXXIII. Syntheses of 8-Alkoxy- and 8-Hydroxy-3-alkyladenines from 3-Alkyladenine 7-Oxides through 7-Alkoxy-3-alkyladenines.

Theoretical EPR study of Nitroindazoles: 3-Alkoxy, 3-Hydroxy and 3-Oxo Derivatives

Um estudo de DFT em derivados 5-NI foi realizado em diferentes níveis de teoria, a fim procurar a melhor metodologia para calcular constantes de acoplamento hiperfinas (hfccs), distribuições da densidade da rotação e propriedades eletrônicas, sabendo-se que é difícil obter boa concordância entre os valores de hfccs calculados e experimentais para compostos radicais centrados no nitrogênio. Os h...

7-3-Chlorophenypiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione as a serotonin receptor ligands with potential antidepressant activity.

BACKGROUND The previous study showed that arylpiperazine can condition affinity to α-adrenoceptors, 5-HT1A/5-HT2A receptors and compounds with arylpiperazine had antidepressant-like effect. The aim of this study was to determine the antidepressant-like activity of new arylpiperazines containing novel 8-alkoxy-purine-2,6-dione fragments. METHODS New 3-chloroarylpiperazinylalkyl analogs of 8-al...

3 4 5 6 7 8

1 Aims: Our main objective was to analyze individual determinants that lead middle-2 aged women to seek medical care for UI. 3 Methods: Observational longitudinal study among GAZEL cohort participants: 2640 4 women aged 50-62 completed a self-administered questionnaire at baseline. Eight 5 years later (2008) 2273 (86%) responded to a follow-up questionnaire. Seeking care 6 for UI was defined as...

Synthesis and Anticonvulsant Activity Evaluation of 3-alkoxy-4-(4- (hexyloxy/heptyloxy)phenyl)-4H-1,2,4 -triazole

A series of 3-alkoxy-4-(4-(hexyloxy/heptyloxy) phenyl)-4H-1,2,4-triazole was synthesized. The anticonvulsant effect and neurotoxicity of the compounds were calculated with maximal electroshock (MES) test and rotarod tests with intraperitoneally injected mice. Among the synthesized compounds, compound 3-heptyloxy-4-(4-(hexyloxy) phenyl)-4H-1,2,4-triazole (5f) was the most active one and also had...

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