Purine analogs as phosphatidylinositol 4-kinase IIIβ inhibitors
نویسندگان
چکیده
منابع مشابه
Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology.
Phosphatidylinositol 4-kinase IIIβ (PI4KB) is indispensable for the replication of various positive-sense single stranded RNA viruses, which hijack this cellular enzyme to remodel intracellular membranes of infected cells to set up the functional replication machinery. Therefore, the inhibition of this PI4K isoform leads to the arrest of viral replication. Here, we report on the synthesis of no...
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Phosphatidylinositol turnover is important in intracellular signal transduction in response to various growth factors, hormones and neurotransmitters1}. Transformation by oncogenes such as ras2^, 5rc3), erbB^, fmsb) and fes^ also enhances cellular phosphatidylinositol turnover. Phosphatidylinositol kinase is an enzyme involved in the pathway of phosphatidylinositol turnover. Especially, its act...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2016
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2016.04.002