Purification of platelet membrane glycoprotein V (GPV).
نویسندگان
چکیده
منابع مشابه
Membrane glycoprotein defects in congenital platelet disorders.
concanavalin A-binding proteins are relatively unaffected by the changes in glucose concentration. At this threshold level of glucose the glucose-regulated proteins of Shui et al. (1977) are not apparent. The reappearance of the 100000-mol.wt. glycoprotein can be correlated with the reappearance of the 95 000-mol.wt. glucosamine-labelled glycoprotein (Fig. 2) and there seems, therefore, good re...
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Engagement of platelet membrane glycoprotein (GP) Ib-IX-V by von Willebrand factor triggers Ca(++)-dependent activation of alphaIIbbeta3, resulting in (patho)physiological thrombus formation. It is demonstrated here that the cytoplasmic domain of GPIb-IX-V associates with cytosolic calmodulin. First, an anti-GPIbalpha antibody coimmunoprecipitated GPIb-IX and calmodulin from platelet lysates. F...
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Platelet membrane glycoproteins (GP) IIb and IIIa form a Ca2+-dependent, heterodimer complex (GP IIb-IIIa) in detergent solution. To determine whether these glycoproteins were complexed or dissociated in intact human platelets, 125I-labeled whole platelets were lysed with an EDTA/Triton X-100 buffer, which stabilized both the complexed and dissociated forms of GP IIb and GP IIIa. The percentage...
متن کاملInfusible Platelet Membrane versus Conventional Platelet Concentrate: Benefits and Disadvantages
Blood transfusion centers are under considerable pressure to produce platelet concentrates with a shelf life limit of 3 to 5 days. Many approaches have been investigated experimentally to produce new hemostatically active platelet products that are capable of long term storage. In this article infusible platelet membrane will be explained as a platelet substitute versus conventional liquid-stor...
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ژورنال
عنوان ژورنال: Blood & Vessel
سال: 1988
ISSN: 0386-9717,1884-2372
DOI: 10.2491/jjsth1970.19.374