Purification, Characterization and Mechanistic Evaluation of Angiotensin Converting Enzyme Inhibitory Peptides Derived from Zizyphus Jujuba Fruit
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چکیده
منابع مشابه
Angiotensin Converting Enzyme Inhibitory Peptides Derived from Cereals
Cardiovascular diseases (CVD) are chronic, lifelong diseases caused by interactions among genetic predisposition, health behaviors and the environment, and are currently the leading cause of mortality and disease burden worldwide. Due to lifestyle and dietary factors, Canadians are at high risk of developing CVD, with nine out of ten individuals over the age of 20 having at least one of the maj...
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To investigate the basic information and the possibility of ACE-inhibitory peptides for antihypertension materials, goat’s caisin (CN) was hydrolyzed by various proteolytic enzymes and ACE-inhibitory peptides were separated and purified. ACEinhibition ratios of enzymatic hydrolysates of goat’s CN and various characteristics of ACE-inhibitory peptides were determined. ACEinhibition ratios of goa...
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Hypertension is an important factor in cardiovascular diseases. Angiotensin-I-converting enzyme (ACE) inhibitors like synthetic drugs are widely used to control hypertension. ACE-inhibitory peptides from food origins could be a good alternative to synthetic drugs. A number of plant-based peptides have been investigated for their potential ACE inhibitor activities by using in vitro and in vivo a...
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Angiotensin I-converting enzyme (ACE)-inhibitory peptides from the thermolysin digest of chicken muscle and the peptic digest of ovalbumin were isolated. However, some of them failed to show antihypertensive activity in spontaneously hypertensive rats (SHR). To clarify this discrepancy, ACE-inhibitory peptides from various sources were preincubated with ACE before measurement of ACE-inhibitory ...
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Jellyfish (Rhopilema esculentum) was hydrolyzed using alcalase, and two peptides with angiotensin-I-converting enzyme (ACE) inhibitory and antioxidant activities were purified by ultrafiltration and consecutive chromatographic methods. The amino acid sequences of the two peptides were identified as VKP (342 Da) and VKCFR (651 Da) by electrospray ionization tandem mass spectrometry. The IC50 val...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-60972-w