Pure red cell aplasia associated with small lymphocytic lymphoma

Pure red cell aplasia and hypogammaglobulinemia associated with Tr-cell chronic lymphocytic leukemia.

A 72-yr-old male with Tr-cell chronic lymphocytic leukemia (Tr-CLL) exhibited pure red cell aplasia (PRCA) and hypogammaglobulinemia. During a remission of Tr-CLL, and while receiving cyclophosphamide therapy, he recovered from PRCA and hypogammaglobulinemia. To investigate the pathogenesis of PRCA and hypogammaglobulinemia, we used coculture techniques to study the effect of the malignant Tr c...

Pure red cell aplasia and associated thymoma

Pure red cell aplasia is a rare cause of anemia, caused by an absence of red blood cell precursors in the bone marrow. It is usually a paraneoplastic syndrome, associated most commonly with large-cell granular lymphocyte leukemia but also thymoma. For patients who present both pure red cell aplasia and thymoma, thymectomy leads to an initial remission of the aplasia in 30% of cases. However, su...

[Pure red cell aplasia associated with renal cell carcinoma].

Refractory pure red-cell aplasia associated with B chronic lymphocytic leukemia successfully treated by fludarabine.

Sir, Pure red cell aplasia (PRCA) is a rare hematologic disorder characterized by a selective erythroid hypoplasia, probably as the result of inhibition of erythropoiesis by T-cells. More than half of the cases remain idiopathic. However, approximately one third are associated with lymphoproliferative disorders. A variety of treatments including prednisolone, cyclosporin A, and cytotoxic chemot...

Pure red cell aplasia associated with large granular lymphocytic leukemia: a rare association in Western countries.

The coexistence of large granular lymphocytic leukemia (LGLL) and pure red cell aplasia (PRCA) has been previously described, but is rare in Western countries (7% in a recent series of LGLL cases). We present the clinical features, hematological parameters and immunophenotype of two patients with PRCA associated with CD3+ LGLL.