Pum 1 sequesters apoptosis during spermatogenesis
نویسندگان
چکیده
منابع مشابه
Pum 1 sequesters apoptosis during spermatogenesis.
R NA binding proteins have long been known to play a role in spermatogenesis. The laboratory of Norman Hecht was one of the leaders in this field, having characterized three RNA binding proteins that regulate mRNAs during sperm differentiation. Polypyrimidine tract-binding protein 2 (PTB2) has two functions—stabilizing mRNA transcripts in the cytoplasm and being involved in splicing. Using in v...
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Cell cycle control during spermatogenesis is a highly complex process owing to the control of the mitotic expansion of the spermatogonial cell population and following meiosis, induction of DNA breaks during meiosis and the high levels of physiological germ-cell apoptosis. We set out to study how E2F1, a key controller of cell cycle, apoptosis, and DNA damage responses, functions in the develop...
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ژورنال
عنوان ژورنال: Asian Journal of Andrology
سال: 2012
ISSN: 1008-682X,1745-7262
DOI: 10.1038/aja.2012.35