Pulsed electromagnetic fields reduce knee osteoarthritic lesion progression in the aged Dunkin Hartley guinea pig

Effect of pulsed electromagnetic field stimulation on knee cartilage, subchondral and epyphiseal trabecular bone of aged Dunkin Hartley guinea pigs.

It has been demonstrated that pulsed electromagnetic field (PEMF) stimulation has a chondroprotective effect on osteoarthritis (OA) progression in the knee joints of the 12-month-old guinea pigs. The aim of the present study was to discover whether the therapeutic efficacy of PEMFs was maintained in older animals also in more severe OA lesions. PEMFs were administered daily (6 h/day for 6 month...

Mesenchymal Stem Cells Transplantation to the Knee Joint of Hartley Strain Guinea Pig with Spontaneous Osteoarthritis

INTRODUCTION Osteoarthritis (OA) of the knee joint is a major public health problem and its prevalence is expected to increase dramatically and rapidly over the next 20 years with an increasingly aged population. It is therefore desirable to develop less technically demanding but effective therapies for knee OA such as cell transplantation with or without scaffold enhancement. The objective of ...

Effect of pulsed electromagnetic fields on the bioactivity of human osteoarthritic chondrocytes.

Low-frequency pulsed electromagnetic fields (PEMFs) are used for the treatment of human osteoarthritic cells in vivo without knowledge of underling principles. The authors evaluated the effect of PEMFs on human chondrocytes of the osteoarthritic knee in vitro. Biopsies of the cut femoral condyles after total knee arthroplasty were kept in a standard cell culture medium consisting of Dulbecco's ...

Pulsed electromagnetic fields and cancer.

Synovial inflammation plays a greater role in post-traumatic osteoarthritis compared to idiopathic osteoarthritis in the Hartley guinea pig knee

BACKGROUND The objective of this study was to evaluate the extent of stromal cell-derived factor-1's (SDF-1) involvement in the pathogenesis of idiopathic versus post-traumatic OA by comparing differences in synovial membrane morphology, SDF-1 synovial fluid (SF) concentrations, and matrix metalloproteinase-13 (MMP-13) SF concentrations. METHODS Thirty-six 3-month-old Hartley guinea pigs were...