Pulse radiolysis studies of 1,8-dihydroxy-9-anthrone (anthralin) under several different conditions
نویسندگان
چکیده
منابع مشابه
SYNTHESIS OF 1, l1-DIHYDROXY-2,2'- (THIODIMETHYLENE) BIS-9(1 OH)-ANTHRONE
An efficient synthesis of the 1,l'-dihydroxy-2,2'-(thiodimethy1ene)bis-9(10H)- anthrone (5) is described. Reaction of 1 -methoxy-2-(bromomethy1)-9,lOanthraquinone (1) with excess sodium sulfide in ethanol, demethylation to the corresponding hydroxy and subsequent selective reduction produced the title compound in high yield.
متن کاملMulti-bromination of 1,8-dihydroxy-9- anthrone, important intermediates in the synthesis of antipsoriatic drugs
10-bromo-1,8-dihydroxy-9-anthrone (10-bromoanthralin) was synthesized with precise ratio of bromine to anthralin (1.10:1), respectively. With this ratio of the reagents, the reaction is repetitive at any scale. This compound is a highly significant intermediate for the synthesis of many anthralin derivetised antipsoriatic drugs. Bromination at both benzylic and aromatic ring positions of anthra...
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Superoxide reductases (SORs) are small metalloenzymes, which catalyze reduction of O2*- to H2O2. The reaction of the enzyme from Treponema pallidum with superoxide was studied by pulse radiolysis methods. The first step is an extremely fast bi-molecular reaction of the ferrous center with O2, with a rate constant of 6 x 10 (8) M(-1) s(-1). A first intermediate is formed which is converted to a ...
متن کاملsynthesis of 1, l1-dihydroxy-2,2'- (thiodimethylene) bis-9(1 oh)-anthrone
an efficient synthesis of the 1,l'-dihydroxy-2,2'-(thiodimethy1ene)bis-9(10h)- anthrone (5) is described. reaction of 1 -methoxy-2-(bromomethy1)-9,loanthraquinone (1) with excess sodium sulfide in ethanol, demethylation to the corresponding hydroxy and subsequent selective reduction produced the title compound in high yield.
متن کاملMechanism of mouse skin tumor promotion by chrysarobin.
The skin tumor-promoting ability of 1,8-dihydroxy-3-methyl-9-anthrone (chrysarobin) was compared with that of 12-O-tetradecanoylphorbol-13-acetate (TPA) and 1,8-dihydroxy-9-anthrone (anthralin) in SENCAR mice. Although dose-response comparisons indicated that chrysarobin was several orders of magnitude less potent than TPA for promoting papilloma formation, this anthrone was 1.5 to 2 times more...
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ژورنال
عنوان ژورنال: Journal of Current Pharma Research
سال: 2010
ISSN: 2230-7834,2230-7842
DOI: 10.33786/jcpr.2010.v01i01.013