Pulpal Response to the Combined Use of Mineral Trioxide Aggregate and Iloprost for Direct Pulp Capping

Purpose: The present study aims to assess the combined effects of mineral trioxide aggregate (MTA) and iloprost when used as a pulp capping material on pulpal inflammation tertiary dentin formation compared with MTA alone in rat molar teeth. Methods: Eighty maxillary first teeth were exposed capped solution, MTA, or mixed (MTA-iloprost). cavities then filled resin-modified glass ionomer. cavity was restored ionomer without use agent control group. rats sacrificed after one four weeks. Block sections specimens prepared subjected hematoxylin eosin staining for evaluation. Statistical analysis done using Kruskal–Wallis test, followed by Dunnett’s test. Results: At week one, group showed significantly more severe inflammatory reactions than (p = 0.00), 0.04), MTA-iloprost 0.00) groups. Hard tissue commonly found iloprost, After weeks, degeneration observed Complete hard barriers 50%, 72.7%, 77.8% groups, respectively, no significant differences among experimental dentinal tubule patterns mostly regular irregular Conclusions: application resulted similar responses mechanically molars. Therefore, mixing might not be clinically significant.