Pulmonary Clearance of Endothelin-1 on Heart Failure: Reduced or Normal?
نویسندگان
چکیده
منابع مشابه
Pulmonary clearance of endothelin-1 on heart failure: reduced or normal?
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متن کاملReduced pulmonary clearance of endothelin-1 contributes to the increase of circulating levels in heart failure secondary to myocardial infarction.
BACKGROUND The pulmonary vascular bed is a major site for endothelin-1 (ET-1) clearance. A reduced clearance could contribute to the increase in circulating ET-1 levels found in heart failure (HF). We therefore evaluated the effect of HF on pulmonary ET-1 clearance and on plasma ET-1 concentrations. METHODS AND RESULTS Rats with myocardial infarction (n=24) were compared with sham-operated ra...
متن کاملEndothelin antagonism in pulmonary hypertension, heart failure, and beyond.
Correspondence to: Professor David J Webb, Clinical Research Centre, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK; [email protected] _________________________ T he discovery in 1988 of endothelin-1 (ET-1) by Yanagisawa and colleagues in Japan represented a landmark in the field of cardiovascular research. A combination of m...
متن کاملElevated endothelin-1 in heart failure and loss of normal response to postural change.
BACKGROUND The possible contribution of endothelin-1, a potent endothelium-derived vasoconstrictor peptide, to neurohumoral compensation for hemodynamic stress was examined in nine normal volunteers and six patients with severe congestive heart failure. METHODS AND RESULTS Plasma levels of endothelin-1 were measured with a sensitive and specific radioimmunoassay. Venous blood samples were obt...
متن کاملActivation of cardiorenal and pulmonary tissue endothelin-1 in experimental heart failure.
Endothelin-1 (ET-1) is a peptide that has been implicated in congestive heart failure (CHF). Although increased concentrations of circulating ET-1 have been repeatedly demonstrated, the activation of local ET-1 in target tissues of CHF remains poorly defined. Our objective was to characterize ET-1 tissue concentrations and gene expression of prepro ET-1 in myocardial, renal, and pulmonary tissu...
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ژورنال
عنوان ژورنال: Circulation
سال: 1999
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.100.25.e135