Pulmonary arterial hypertension: In Asia, as elsewhere, still a lethal disease despite modern treatment
نویسندگان
چکیده
منابع مشابه
CCR5 as a treatment target in pulmonary arterial hypertension.
BACKGROUND Pulmonary arterial hypertension (PH), whether idiopathic or related to underlying diseases such as HIV infection, results from complex vessel remodeling involving both pulmonary artery smooth muscle cell (PA-SMC) proliferation and inflammation. CCR5, a coreceptor for cellular HIV-1 entry expressed on macrophages and vascular cells, may be involved in the pathogenesis of PH. Maraviroc...
متن کاملModern age pathology of pulmonary arterial hypertension.
RATIONALE The impact of modern treatments of pulmonary arterial hypertension (PAH) on pulmonary vascular pathology remains unknown. OBJECTIVES To assess the spectrum of pulmonary vascular remodeling in the modern era of PAH medication. METHODS Assessment of pulmonary vascular remodeling and inflammation in 62 PAH and 28 control explanted lungs systematically sampled. MEASUREMENTS AND MAIN...
متن کاملPulmonary veno-occlusive disease misdiagnosed as idiopathic pulmonary arterial hypertension.
A 27-yr-old female with a 6-month diagnosis of idiopathic pulmonary arterial hypertension (PAH) confirmed elsewhere was referred to our centre with worsening dyspnoea. On examination, the patient had low systemic oxygen saturation despite high oxygen flow and reduced exercise capacity. Haemodynamics were indicative of severe pre-capillary PAH. High-resolution computed tomography revealed diffus...
متن کاملPulmonary arterial hypertension: many years' experience and modern approach to a malignant disease in a pulmonary hypertension centre.
INTRODUCTION The aim of this study was to record the results from a modern diagnostic and therapeutic approach to patients with pulmonary arterial hypertension. METHODS We studied the clinical characteristics and the treatment of 69 patients (50 women, 72.5%), aged 44 +/- 17 years, who were diagnosed with pulmonary hypertension (World Health Organisation categories I, IV and V). The patients'...
متن کاملTreatment of pulmonary arterial hypertension.
the authors reply: Arias et al. correctly note that diabetes is an independent risk factor for congestive heart failure. Data from the Cardiovascular Health Study have also shown a significant independent relationship between diabetes and the development of congestive heart failure1; most cases of heart failure in that cohort were associated with a normal or near-normal ejection fraction — that...
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ژورنال
عنوان ژورنال: Respirology
سال: 2018
ISSN: 1323-7799
DOI: 10.1111/resp.13438