Publication Rate and Characteristics of Lung Cancer Clinical Trials

Characteristics of Clinical Trials in Iran: A Sample of 5000 Trials Registered in IRCT

Background and Objectives: A considerable number of clinical trials are conducted in Iran each year. Not much is known about the characteristics of them, this study aimed to investigate key characteristics of Iranian clinical trials.   Methods: All clinical trial protocols registered in IRCT until November 2013 were selected. Text mining techniques were used to extract information from data t...

Putting lung cancer clinical trials into perspective.

Ganti and colleagues have provided a comprehensive overview on recent presentations involving lung cancer. However, several of the points they made in the article deserve to be put in perspective, particularly since most of the studies discussed are small phase II trials that have not yet been published. Thus, it is important to put these findings in context with the peer-reviewed and randomize...

Registration of clinical trials for publication.

Prevalence, characteristics, and publication of discontinued randomized trials.

IMPORTANCE The discontinuation of randomized clinical trials (RCTs) raises ethical concerns and often wastes scarce research resources. The epidemiology of discontinued RCTs, however, remains unclear. OBJECTIVES To determine the prevalence, characteristics, and publication history of discontinued RCTs and to investigate factors associated with RCT discontinuation due to poor recruitment and w...

Evaluation of Clinical Trials

In a number of important clinical issues such as evaluation of the efficacy or effectiveness of therapeutic or preventive interventions as well as for comparing the harms of interventions, randomized controlled trials (RCTs) provide the highest levels of evidence, either directly or indirectly. It is obvious that critical appraisal of these studies to assess their validity and precision is of p...