pUBLically unzipping Parkin: how phosphorylation exposes a ligase bit by bit
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چکیده
منابع مشابه
pUBLically unzipping Parkin: how phosphorylation exposes a ligase bit by bit.
A ccumulation of damaged mitochondria is prevented by their disposal through mitophagy, a mitochondrial quality control pathway. The protein kinase PINK1 and the E3 ubiquitin (Ub) ligase Parkin cooperate to initiate mitophagy by selective ubiquitination of protein substrates located on the mitochondrial outer membrane. Function-compromising mutations in PINK1 and Parkin genes predispose to here...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2015
ISSN: 0261-4189,1460-2075
DOI: 10.15252/embj.201592857