<p>Therapeutic compounds targeting Lipid II for antibacterial purposes</p>
نویسندگان
چکیده
منابع مشابه
The lantibiotic mersacidin inhibits peptidoglycan synthesis by targeting lipid II.
The lantibiotic mersacidin exerts its bactericidal action by inhibition of peptidoglycan biosynthesis. It interferes with the membrane-associated transglycosylation reaction; during this step the ultimate monomeric peptidoglycan precursor, undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)-GlcNAc (lipid II) is converted into polymeric nascent peptidoglycan. In the present study we demonstrate th...
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Colicins are proteins produced by some strains of Escherichia coli to kill competitors belonging to the same species. Among them, ColM (colicin M) is the only one that blocks the biosynthesis of peptidoglycan, a specific bacterial cell-wall polymer essential for cell integrity. ColM acts in the periplasm by hydrolysing the phosphoester bond of the peptidoglycan lipid intermediate (lipid II). Co...
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ژورنال
عنوان ژورنال: Infection and Drug Resistance
سال: 2019
ISSN: 1178-6973
DOI: 10.2147/idr.s215070