<p>The PPARγ Agonist Rosiglitazone Enhances the Radiosensitivity of Human Pancreatic Cancer Cells</p>
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چکیده
منابع مشابه
Modulation by the PPARγ Agonist Rosiglitazone
Early after stroke onset, ischemic injury is exacerbated by a robust inflammatory response that involves a local reaction as well as an influx of blood-borne cells recruited by cytokines, adhesion molecules, and chemokines. Among these cells, neutrophils are rapidly mobilized from the bone marrow to provide an effective innate immune response; they rapidly infiltrate into the ischemic brain (a ...
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BACKGROUND Neointimal hyperplasia involving smooth muscle cell (SMC) proliferation, migration and extracellular matrix (ECM) degradation is an important component of atherosclerosis. It develops as a response to vascular injury after balloon angioplasty and vascular graft placement. Matrix metalloproteinases (MMPs) induce SMC proliferation, migration and contribute to intimal hyperplasia by deg...
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Objective: To investigate the effects of AZT-mediated inhibition of telomerase activity on the proliferation, apoptosis and radiosensitivity of panc1 cells, and the growth of pancreatic tumor in vivo. Methods: panc1 cells were divided into four groups: A, control group; B, 0.4 mmol/L AZT; C, 0.6 mmol/L AZT; and D, 0.8 mmol/L AZT group. Cell proliferation was assessed by MTT assay. Cell apoptosi...
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Evidence had shown the detrimental effect of prostaglandin (PG) E2 in diabetic nephropathy (DN) of STZ-induced type-1 diabetes but its role in the development of DN of type-2 diabetes remains uncertain. The present study was undertaken to investigate the regulation of PGE2 synthetic pathway and the interaction between peroxisome proliferator-activated receptor (PPAR) γ and PGE2 synthesis in the...
متن کاملRosiglitazone activation of PPARγ suppresses fractalkine signaling
The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) is a key transcriptional regulator of both lipid metabolism and inflammation. The importance of PPARgamma is accentuated by the widespread use of synthetic PPARgamma agonists, thiazolidinediones (such as rosiglitazone), as drugs for insulin resistance and type II diabetes. Fractalkine (FKN) and FKN receptor (FR) p...
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ژورنال
عنوان ژورنال: Drug Design, Development and Therapy
سال: 2020
ISSN: 1177-8881
DOI: 10.2147/dddt.s242557