PTEN Regulates PDGF Ligand Switch for β-PDGFR Signaling in Prostate Cancer
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چکیده
منابع مشابه
TITLE: PTEN Regulates β-Catenin in Androgen Signaling; Implication in Prostate Cancer Progression PRINCIPAL INVESTIGATOR:
Although the vital role of the androgen receptor (AR) has been well demonstrated in primary prostate cancers, its role in the androgen-insensitive prostate cancers still remains unclear. Here, we used a small hairpin RNA approach to directly assess AR activity in prostate cancer cells. Reduction of AR expression in the two androgen-sensitive prostate cancer cell lines, LNCaP and LAPC4, signific...
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The platelet-derived growth factors (PDGF A, B, C, and D) and their receptors (α-PDGFR and β-PDGFR) play an indispensible role in physiologic and pathologic conditions, including tumorigenesis. The transformative β-PDGFR is overexpressed and activated during prostate cancer progression, but the identification and functional significance of its complementary ligand have not been elucidated. This...
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Apart from their endocrine functions renin-expressing cells play an important functional role as mural cells of the developing preglomerular arteriolar vessel tree in the kidney. The recruitment of renin-expressing cells from the mesenchyme to the vessel wall is not well understood. Assuming that it may follow more general lines of pericyte recruitment to endothelial tubes we have now investiga...
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Increasing evidence indicates the significance of platelet-derived growth factor receptor-b (b-PDGFR) signaling in prostate cancer (PCa). Accordingly, preclinical studies suggest the potential of b-PDGFR as a therapeutic target in metastatic PCa. However, a ligand responsible for b-PDGFR activation in PCa was unknown, and recent clinical trials with imatinib mesylate showed limited success due ...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2012
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2011.11.021