PTEN Regulates PDGF Ligand Switch for β-PDGFR Signaling in Prostate Cancer

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Although the vital role of the androgen receptor (AR) has been well demonstrated in primary prostate cancers, its role in the androgen-insensitive prostate cancers still remains unclear. Here, we used a small hairpin RNA approach to directly assess AR activity in prostate cancer cells. Reduction of AR expression in the two androgen-sensitive prostate cancer cell lines, LNCaP and LAPC4, signific...

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ژورنال

عنوان ژورنال: The American Journal of Pathology

سال: 2012

ISSN: 0002-9440

DOI: 10.1016/j.ajpath.2011.11.021