PTEN gene and AKT/mTOR pathway in gynecological cancers and cancer immune escape

Gynecological cancers (GCs) include cervical, uterine, ovarian, vulvar and vaginal cancer. For women in China, 2 of the 10 most common are GCs (8th: cervical cancer, incidence rate: 3.96%; 10th: ovarian 2.91%). These can lead to enormous psychological economic burdens. Phosphatase tensin homolog (PTEN) gene protein kinase B (AKT) mammalian target rapamycin (mTOR) pathway widely involved development GCs, an imbalance regulatory T cells (Treg) cancer micro-environment mediated by PTEN AKT/mTOR was shown cell immune escape, growth metastasis. Considering that pathogenesis escape remains unclear, this review article intends provide update field. We made a comprehensive search several databases, including Web Science, MEDLINE, Ovid Cochrane Database Systematic Reviews, conducted from inception March 2022. The strategy included combinations following medical terms: gynecological cancers, uterine gene, pathway, escape. found currently mechanism is not fully clear. However, activation signaling Treg caused function loss occurrence related prognosis patients. This presented latest research progress on